Liquid Chromatography Essentials (CE Module 2)

Course Description:

This module focuses on practical execution of liquid chromatography, covering LC system setup, operation, and troubleshooting. Learners examine the LC flow path and the roles of system components including the solvent reservoir, degasser, pump, autosampler, column, detector, and data system. The course also addresses solvent handling, degassing, priming, pressure monitoring, and leak detection to ensure stable operation and reproducible data. Participants learn to select columns, mobile phases, and detectors while applying isocratic or gradient strategies and structured troubleshooting approaches to LC performance issues. The course closes with a deep dive into 5 possible detectors for liquid chromatographs, highlighting each detector’s use-cases, strengths, and weaknesses.

Recommended Learners:

Toxicologist

Makayla Chipka

Makayla J. Chipka, M.S. is an analytical chemist, laboratory consultant, and regulatory expert with extensive experience in drug of abuse analysis, forensic toxicology applications, and analytical method development. See full bio.

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Course Content

Course materials are available exclusively to enrolled students.

Enrollment includes access to downloadable handouts and a Course Information Packet designed to support your completion certificate and assist in applying for Continuing Education Units (CEUs) from organizations that do not automatically pre-approve our courses.

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Course Materials

These downloadable resources support your training and assist with documentation for Continuing Education Unit (CEU) credit.