Clozapine – Unpacking the Complexities of a Unique Antipsychotic

On this episode of The Tox Lab, the hosts take a closer look at clozapine, a highly effective antipsychotic with a complex toxicological profile. They review a study from Western Sydney examining cases of self-poisoning and adverse drug reactions, discuss a case of chronic clozapine toxicity, and explore new research into its effects on cardiac mitochondria. From clinical outcomes to cellular mechanisms, the hosts unpack the risks, challenges, and unanswered questions around this fascinating but unpredictable drug.

Links to papers discussed:

Toxicity and Adverse Effects in Clozapine-Related Presentations to a Medical Toxicology Service in Western Sydney

Beyond Acute Overdoses: A Case of Chronic Clozapine Toxicity With Non-specific Presentation

Acute exposure to clozapine and sodium valproate impairs oxidative phosphorylation in human cardiac mitochondria